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A clinical insight in JAMA Internal Medicine makes the same point from the clinics perspective: diet and physical activity, it argues, remain crucial when prescribing GLP1s especially for protecting muscle, maintaining adequate nutrition, and turning shortterm weight loss into durable health gains

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Hermansen K, Bkdal TA, Dring M, Pietraszek A, Mortensen LS, Jrgensen H, et al

When cellular glutathione levels drop, the accumulation of unneutralized reactive oxygen species provokes mast cells to become hyper-reactive, inappropriately releasing massive quantities of histamine into the bloodstream