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Semaglutide has been extensively studied, with multiple clinical studies proving that it is safe and effective in the treatment of type 2 diabetes, obesity, chronic kidney disease and cardiovascular disease Semaglutide, a GLP-1 receptor agonist, has been shown in multiple clinical trials to be effective for the treatment of type 2 diabetes

The physiologic significance of these numerous actions has not been established.25 The pattern of PYY secretion in response to a meal raises the hypothesis that it may play a role as physiologic satiety signal, acting in terminating the meal and stimulating coordinated gastrointestinal responses in order to aid digestion and absorption

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