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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

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Clinical Data Clinical Trial Results 28.7% Average Weight Loss 68 weeks 58.6% Achieved 25%+ Loss of participants 445 Trial Participants Phase 3 Data from the Phase 3 TRIUMPH-4 trial of retatrutide, reported by Eli Lilly (topline, 2025)

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