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Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

Semaglutide is currently FDA-approved for chronic weight management under the brand name Wegovy, with efficacy data from the STEP clinical trials supporting its use in adults with obesity or overweight with related comorbidities

The metabolic adaptations are largely complete, eating patterns have normalized around reduced portions, and the body has established new hormonal set points

For weight loss, semaglutide is available as a once-weekly injection and as a daily pill