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Researchers utilizing S4 may counteract vision deterioration by enhancing eye health with the following supplements: Vitamin A: 3,000 IU (900 mcg) per day Lutein: 10 mg per day Zeaxanthin: 2 mg per day Relevant Research A SARM, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway Exploring the potentials of S4, a SARM, in glioblastoma multiforme therapy S23 In preclinical research published in Endocrinology , S23 temporarily impaired spermatogenesis (sperm production) in rats