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Zeng Q, Junli G, Liu X et al (2019) Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis

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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates

Additionally, inhibition of PKC was shown to reduce NRF2 phosphorylation and transcriptional activity, along with the expression and activity of NRF2-regulated antioxidant proteins [43]