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The STEP 1 extension found that the cardiometabolic improvements seen during treatment including blood sugar, blood pressure and cholesterol largely reverted toward baseline within a year of stopping

However, tesofensine, being a pharmaceutical intervention, may carry certain risks

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After consideration of public comments we received, we are finalizing our proposal to use the most recently available pre-floor and pre-reclassified IPPS hospital wage indexes to the labor-related share to create the final CY 2026 ASC wage indexes and to limit wage index decreases by no more than 5 percent from the final CY 2025 ASC wage index for a particular CBSA