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Collectively, current evidence supports a model [Figure 1B] in which: (1) a large fraction of early MASH resolution in ESSENCE is likely explained by significant weight loss and associated metabolic reprogramming

Within 7296 hours of discontinuation, most users report a noticeable return of appetite, often described as a rebound effect: hunger signaling feels more intense than baseline because MC4R receptors, previously saturated with exogenous agonist activity, are now upregulating and re-sensitizing to endogenous alpha-MSH

Medication Adherence Taking medication exactly as prescribed is important for maximizing effectiveness