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Lilly said retatrutide helped relieve obesity-linked conditions including knee pain, sleep apnea, and type 2 diabetes

If the regained weight is disproportionately fat, individuals may ultimately be worse off than before in their fat-to-lean mass ratio, which may have adverse consequences for their health. The researchers say there are several limitations to their study

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Extra provider scrutiny is warranted for patients with hepatic impairment (Child-Pugh B or C), significant renal impairment (eGFR below 30), high-dose zinc supplementation (above 50 mg/day), active infection at the intended injection site, or age under 18