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It's important to consider other potential causes, including concurrent medications (such as metformin), vitamin deficiencies, or oral/dental conditions

doi: 10.1016/j.joca.2014.09.024 91

Prooxidant properties of naringenin may cause cytotoxicity to various cancer cell lines, apoptosis, and activation of one of the Mitogen-activated protein kinases, ASK1 resulting in apoptosis by ROS-mediated activation of ERK1/2 (Park et al