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When water enters the skin, it hydrates cells as well as the extracellular matrix, which can reduce the appearance of fine lines and wrinkles [1]

The primary endpoint will be bodyweight change (week 80 and 104), change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in the OA subset, and change in Apnoea-Hypopnea Index (AHI) in the OSA subset

The magnitude of IGF-1 increase varies by dose, duration, and individual responsiveness but is a reproducible finding across clinical practice and the smaller body of formal studies