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For the single-cell RNA sequencing analyses, healthy controls were derived from publicly available external datasets rather than controls processed in parallel with our patient samples, which may introduce batch effects

Intriguingly, MM cells without mutations in BRAF or NRAS mutations tend to exhibit CCND1 or CDK4 amplification (122), suggesting that copy number variations of cell cycle regulatory genes act as an alternative driver and can substitute for BRAF or NRAS mediated proliferation signaling pathway activation

[DOI] [PubMed] [Google Scholar] 31.Szpechcinski A., Chorostowska-Wynimko J., Struniawski R., Kupis W., Rudzinski P., Langfort R., Puscinska E., Bielen P., Sliwinski P., Orlowski T