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Most notice appetite changes by week 3-4 and average 24.2% weight loss by week 48

T., Dekker, C., Reardon, P

found that while macaques immunized with a modified vaccinia Ankara viral vector expressing the SARS-CoV S protein had reduced viral replication after challenge, anti-S IgG also enhanced pulmonary infiltration of inflammatory macrophages and resulted in more severe lung injury compared to unvaccinated animals 66