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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful

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Pituitary signaling controls the selective GH response by integrating receptor activation with intracellular pathways specific to somatotroph cells