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Peer-reviewed literature indexed on PubMed Reviews GHK-Cu modulation of gene expression related to tissue remodeling and anti-inflammatory pathways

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This redefinition emerged from international consensus discussions among major hepatology societies and represents a deliberate shift from an exclusion-based diagnosis toward a positive, etiology-driven framework that better reflects the underlying metabolic and inflammatory pathophysiology of the disease (Girish and John, 2025)