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Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy

In pancreatic cells, activation of these G proteincoupled receptors primarily signals through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

In the context of cerebral ischemia, astrocytes are especially important in regulation and maintenance of glutamate during acute injury, which causes excitotoxicity and perturbates calcium influx resulting in cell death ( Per2, Clock , and NPAS2 display significant reductions in glutamate uptake, mRNA expression of Glast, an astrocyte-specific glutamate transporter, and protein expression (Sofroniew, 2015)

Risk of major adverse cardiovascular events and all-cause mortality under treatment with GLP-1 RAs or the dual GIP/GLP-1 receptor agonist tirzepatide in overweight or obese adults without diabetes: a systematic review and meta-analysis