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Imbalance in the oxidant-antioxidant system in psoriasis is involved

Figure 3, Source: PHG Earnings Report To be as endearingly direct as the Dutch tend to be - I think not

These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane