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A cost-effectiveness analysis compared FDA approved fibromyalgia (FM) drugs (pregabalin, duloxetine, milnacipran) with amitriptyline and found duloxetine was the preferred strategy across perspectives

Inflammation also modulates synaptic function through signaling pathways such as BDNFTwo-pore-domain potassium channel TREK-1 (TREK-1) and Phosphoinositide 3-kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR)