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Injection is significantly more effective and consistent

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The IADVL 2017 Position on Skin Lightening Agents takes a careful line on intravenous glutathione: the FDA has not approved it for cosmetic indications, the dermatology evidence base shows modest tyrosinase-inhibition effect with topical pigment control doing most of the visible work, and the off-label cosmetic use sits firmly outside a curative claim

A crucial observation was that DSIPs activating effect on oxidative phosphorylation was selective, primarily increasing V3 without affecting VDNP, and showing no evidence of uncoupling oxidative phosphorylation