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Dual agonists that activate both GLP-1 and GIP receptors tend to cause these side effects slightly more frequently than pure GLP-1 agonists

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Specifically, a phase 2 clinical trial (NCT01839344) measured the effect of Que on glucose tolerance and postprandial endothelial function in subjects with T2D compared to the effect of an alpha-glusidase inhibitor, acarbose