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Previous studies have shown that the sustained loss of GABAergic interneurons induced by ketamine was linked to an upregulation of the enzyme responsible for the synthesis of superoxide radicals, which are responsible for stereotypical behaviors and depression (21, 85)

doi: 10.3390/app10030947 75 ScheibeR.BackhausenJ

It's also adhesions, organ tethering, scar tissue, thickened tissue, uh, pain that gets worse over time because of how things are pulling on the structures