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Among 56 enrolled congenital hypothyroid patients, the majority were suffering from dyshormonogenesis (50%, n = 28), whereas about 27% (n = 15), 9% (n = 5), 3% (n = 2) and 2% (n = 1) patients had etiologies of thyroid gland agenesis, thyroiditis, hypoplasia and ectopic thyroid gland, respectively (Table 2)

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In the U.S., GLP-1 prescriptions more than doubled in just 18 months, topping nine million by early 2024

Substitutions in the amyloidogenic core region were used to disrupt the beta-sheet propensity that drives fibril nucleation, allowing the analog to remain soluble and monomeric at formulation-relevant concentrations