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The mechanism of action centers on mimicking endogenous GLP-1, an incretin hormone secreted by intestinal L-cells in response to nutrient intake

The bodys metabolic changes, triggered by uremia, can cause certain effects, like fatigue due to anemia

Metoclopramide , commonly used for nausea and digestive issues, crosses into the brain and blocks dopamine receptors

The dual actions of GLP-1 RAs, namely, the promotion of insulin secretion and the inhibition of glucagon release, exert a significant influence on the plasma ratio of these hormones, thereby contributing to the maintenance of glucose homeostasis in the body