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Topical application is limited by the stratum corneum barrier, with near-zero penetration through intact skin (Li et al., 2015)

This process, known as lipolysis, involves the release of fatty acids from fat cells, allowing the body to use them as energy

It was the first peptide shown to be encoded by mitochondrial DNA that acts as a systemic hormone

Comment: A commenter mentioned our proposed regulation text edits and noted that the changes discussed in the preamble did not align with what was included in the regulation text at the end of the proposed rule and suggested that there may have been an inadvertent drafting error