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No unique adverse effects emerge from combining these therapies compared to GLP-1 monotherapy

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Change from baseline at Week 72 in HbA1c, percent change from baseline at Week 72 in body weight, fasting insulin, and HOMA2 parameters (i.e., HOMA2-IR, HOMA2-S and HOMA2-B) were assessed using mixed model for repeated measures with treatment group, time, treatment-by-time interaction, prediabetes status at randomization, sex, and BMI category as fixed effects, and baseline value of the response variable as a covariate and reported as least squares means and standard errors with fasting insulin and HOMA2 parameters reported as overall baseline geometric mean, estimate (standard error) actual values and percent change from baseline at Week 72 using log transformation