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The development of Parkinson's disease is believed to begin during the premotor phase, affecting various regions of both the peripheral and central nervous systems, as well as the dopaminergic neurons located in the substantia nigra pars compacta [11]

Because GHK-Cu is researched for regenerative, tissue-remodeling, collagen-related, and cellular-signaling pathways, research involving active or suspected malignancies, copper-metabolism conditions, liver-related investigations, or complex dermatological research models may warrant additional monitoring and individualized evaluation

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Conversely, treatment with the D3 selective antagonist NGB 2904 alone rendered mice susceptible to depression-like effects and caused changes similar to the LPS-induced alterations in the mPFC and NAc (Wang, Xu et al., 2018)