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Binding of GABA to GABA A receptor induces the opening of the ligand-gated chloride channel, leading to an increased influx of chloride ions, which results in hyperpolarization

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Specifically, one commenter suggested that CMS consider unpackaging their product, a contrast agent, and believed CMS's reasoning in the CY 2026 OPPS/ASC proposed rule for unpackaging and paying separately for diagnostic radiopharmaceuticals applies equally or even more to their product, since the cost of their product is over 500 times greater than the amount reported for the policy packaged drugs offset associated with the Level II Urology APC

10.1021/jm200036n 9 AnderssonH.DemaegdtH.VauquelinG.LindebergG.KarlnA.HallbergM