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Increased clinical experience and successful treatment of patients using relatively high quantities of insulin resulted in the current dosing strategy typically suggested in the medical literature ( table 1 )

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It is distinguished in the research literature by its selectivity: published pre-clinical work reports it stimulates GH release without significantly elevating cortisol, prolactin, or ACTH, unlike earlier secretagogues in its class

2 The NHS is now prioritising newer medications like Mounjaro, which received broader NICE approval in 2024