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Clinical uses of GLP-1: Obesity and its link to unhealthy aging Obesity is a significant modifiable contributor to unhealthy aging, accelerating the onset of CVDs, T2D, neurodegeneration, and certain cancers through chronic inflammation, oxidative stress, mitochondrial dysfunction, and disrupted insulin signaling

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18.5-22.9 Healthy 23.0-27.4 Overweight Diet + Exercise 27.5-37.4 Obese Medication + Lifestyle 37.5 Severely Obese Consider Surgery Key threshold: BMI 27.5 = eligible for prescription medication

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