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Given the substantial disease burden and adverse health outcomes associated with this comorbidity, interventions aimed at reducing this risk for depression in the Type 2 diabetes population are crucial, particularly among older adults who are disproportionately affected by both conditions. Guo noted that previous research suggested that GLP-1RAs a drug also used to treat obesity and kidney disease may alleviate depression symptoms due to its ability to cross the blood-brain barrier

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In addition, a near-infrared II (NIR-II) fluorescence/photoacoustic nano-inducer I/E@M2pep which can be activated by nitric oxide (NO), where the M2pep peptide can target M2 TAMs and IPI549 reprograms them into an M1 phenotype, and can significantly enhance antitumor immunity through M1 TAM-mediated tumor killing and TME remodeling when combined with a CD47 monoclonal antibody (57)

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