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Rare hypersensitivity or allergic reactions may occur in individuals sensitive to the cyanide molecule, though this is extremely uncommon at the microdose levels used in medical formulations

Inflammatory markers such as C-reactive protein (CRP) and inflammatory interleukins (IL), such as IL-1, IL-6 and tumor necrosis factor- (TNF-), increase as well [8,9,10,11]

GPER-1 belongs to the family of G protein-coupled receptors, and, in humans, its gene is located in chromosome 7p22.3, which encodes a sequence of 375 amino acids with a relative molecular mass of 41 kDa

Alternative approaches are typically recommended in these cases