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Your body excretes what it doesnt use via urine

Compared to these studies, contrasting results have been collected from a big multicenter phase III RCT (the PIVENS trial) which involved 247 non-diabetic patients with biopsy-proven NASH and compared vitamin E versus pioglitazone versus placebo after a 96-week treatment period

AL has received honoraria lecture and/or consulting fees from Ionis, Ipsen, Merck, Novartis, Pfizer, Sandoz

However, such a benefit might not be seen with DPP-4 inhibitors, since these drugs primarily potentiate levels of GLP-1 in the gastrointestinal tract and have modest effects on GLP-1 receptors in the systemic circulation [4]