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Abstract Purpose of Review This review provides practitioners with an up-to-date overview of the efficacy and safety data of the currently approved weekly Nutrient-Stimulated Hormone (NuSH) therapies, semaglutide and tirzepatide, in managing obesity and weight-related comorbidities

328 Although GNMT is considered a novel therapeutic target for DKD, treatment strategies targeting GNMT may need to account for individual differences, such as genetic polymorphisms, disease stage, and comorbidities, all of which could influence treatment outcomes