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Commonly reported side effects include: Nausea, vomiting, and diarrhoea particularly during dose escalation Constipation and abdominal discomfort Decreased appetite and early satiety Injection site reactions (mild and transient) Fatigue, especially in the initial weeks of treatment These gastrointestinal effects are consistent with the GLP-1 mechanism and are generally dose-dependent and transient

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Other publications discussed: user-friendly intuitive eCOA design, flexible data collection and monitoring methods, patient-centered protocol design, and comprehensive participant and site training

GIP Receptor Activation: Insulinotropic Action: Stimulation of GIP receptors augments insulin secretion in response to nutrient ingestion, working synergistically with GLP-1 to improve overall glucose homeostasis