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As expected for the intended effect of ADT, metabolite set enrichment analysis (MSEA) of the significantly different metabolites revealed steroid hormone biosynthesis pathways, including androstenedione metabolism as well as androgen and estrogen metabolism, to be overrepresented by metabolites that were significantly different between +ADT and ADT groups (Figure 1E)

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BH3-only proteins such as Bad support this process by neutralizing anti-apoptotic Bcl-2 members