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If you notice blood in your stools, significant unintentional weight loss beyond what is expected from the medication, or symptoms of anaemia such as extreme fatigue and pallor, these could indicate conditions requiring investigation beyond IBS and should be evaluated promptly

The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans

Some patients remain at one dose long-term as a maintenance dose

Compounded semaglutide is a legal alternative where licensed pharmacies produce the same active ingredient at a significantly lower cost, making treatment accessible to patients without insurance coverage