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Acknowledgments This study was supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R23), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Preclinical evidence from the Sikiric lab and collaborators describes protective effects against ethanol-induced gastric lesions, NSAID-induced enteropathy, and ileoileal anastomotic disruption in rat models, with the latter studied under the Pliva clinical-development code PL-14736 (Tkalcevi et al., 2007