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"So the answer depends very much on the patient, their clinical history, and the context in which the drug is prescribed." A Call For 'Personalized' Care Hardaway told Newsweek that, as GLP-1s could have mixed effects on different patients, he "would like to see GLP-1s enter into a zone of personalized medicine." He said it is important to consider whether it is possible to "titrate dosage" to each patient to "achieve the clear medical benefits of these drugs without side effects or potential abuse," and whether it is possible to "produce weight loss and medical benefits that are more lasting and durable." He said that titrating dosage and potential personalization is "experiential at the moment, and physicians are doing all of this off-label." He added: "That's fine over the short term, but one physician prescribing a low-dose GLP-1 analog because they think it will contribute to 'longevity' and pushing that recommendation on Instagram is just informed guesswork." "We need more science and rigorous clinical trials to sort this out," he said