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For example, disruption of CRHR2 signaling in pancreatic SST-producing cells has been shown to contribute to diabetes development 8

In all studies, pre-emptive therapy was associated with high rates of side effects, including rejection and unrelated deaths, and a large proportion of patients required dose reductions

Notably, a seven-day regimen of intraperitoneal administration of the GLP-1 analog Exendin-4 has been observed to attenuate anxiety-like behaviors in mice undergoing heroin withdrawal