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staff at the Mass Spectrometry Resource Laboratory in the Center for Advanced Research Technologies (CART) and the Histology, Biochemistry, and Molecular Imaging (HBMI) Core at the Center for Musculoskeletal Research (CMSR) at URMC, the Proteomics/Metabolomics Core at Moffitt Cancer Center, which is funded in part by Moffitts Cancer Center Support Grant (P30CA076292), and University of Chicago Metabolomics Platform (RRID: SCR_022932)

With an aim to understand how decreased GNE expression might affect sialylation and function of IGF-1R, we first determined sialylation levels of IGF-1R in GNE knockdown cells by immunoblotting

10,11 These tangles impair synaptic transmission between neurons by interfering with the transport system inside the neuron

Escames, G