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Hydration matters enormously in the post-injection window

Couture Med Spa reports a similar pattern among its own tirzepatide and semaglutide patients, listing mild nausea or upset stomach, temporary irritation at the injection site, fatigue or headaches, and changes in appetite, and adds that most side effects fade as the body adjusts to treatment (couturemedspa.com)

How to self inject GLP-1 or Tirzepatide medication (Subcutaneous Injection) Dosing and Step-by-Step Instructions Medication Specific Questions All medications should be refrigerated when they are received

They tend to peak in the first few weeks and improve as the body adapts, often within four to eight weeks