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These reactions typically manifest as localized skin changes at or near the injection site and are generally mild to moderate in severity

Mitchell JE, Christian NJ, Flum DR, Pomp A, Pories WJ, Wolfe BM, et al

Several studies have shown that prophylactically lithium can reduce manic relapses, even if its efficacy is significantly lower in the reduction of depressive relapses 18

[PubMed] [PMC] Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR (2021) Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic -oxidation