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Among the effects provided by melatonin administration, the modulation of N -methyl-d-aspartate (NMDA) receptors and the conservation of myelin sheets in the central nervous system (CNS) are probably the least treated

Although transepithelial electrical resistance and the movement of marker solutes is frequently used to measure paracellular permeability, only a small number of publications have directly documented paracellular movement of solutes by autoradiography, in vivo confocal microscopy, or electron microscopy [25,26,27,28] whereas for most cases, the differentiation of paracellular from transcellular movement has been indirect [23, 29]

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HLRCC syndrome is caused by an autosomal dominantly inherited mutation of the fumarate hydratase ( FH ) gene (Tomlinson et al., 2002)