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Normal saline (0.9% sodium chloride) can technically dissolve semaglutide, but it is not recommended for multi-dose vials

IMPORTANT PRESCRIBER & PATIENT NOTICE This preparation is compounded only when the prescribing practitioner documents that the FDA-approved product does not meet the patients medical needs (e.g., different strength, excipient profile, or delivery route)

Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

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