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Future studies with animal models and human subjects are warranted to test this hypothesis

While GLP-1R peptide agonists bind both the ECD and the TMD, the role of the interactions with each domain differs among peptides

Furthermore, GLP-1 has been shown to downregulate inflammatory and oxidative stress pathways that are linked to atherosclerosis development [9,10,11]

Specifically, human FLNA, mapping to Xq28, is the first actin filament cross-linking protein identified in non-muscle cells (71) and is the most abundant filamin isoform in adults