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However, given that GLP-1R agonism in the VTA more robustly suppresses the intake of highly palatable foods compared to normal chow in drug-nave rodents 37,45,46 , it is likely that endogenous GLP-1 signaling in the VTA more selectively regulates hedonic rewards versus homeostatic signals 4

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While a protein-restricted diet reduces protein and amino acid intake to mitigate propionyl-CoA synthesis from propiogenic amino acids, fasting triggers broader metabolic alterations