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In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity
Long-term dosing considerations Both compounds are intended for long-term use
For other ratios, researchers reconstitute separate vials and combine in solution
By contrast, Trx1 protects against apoptosis through ASK1 and JNK inhibition, demonstrating their opposing regulatory roles in cell fate decisions (167,168)
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