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The main mechanism of action of Phentermine/Topiramate extended release(ER) is possibly the alteration of various neurotransmitters, including inhibition of voltage-dependent sodium channels, glutamate receptors, and carbonic anhydrase as well as potentiation of -aminobutyrate activity (83).Two large randomized, double-blind, placebo-controlled trials took place (EQUIP and CONQUER) followed by a 2-year extension trial (SEQUEL)

Patients often take B12 shots to improve their mood and energy levels, since B12 supports the production of serotonin and dopamine and encourages the conversion of food to energy

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doi: 10.1073/pnas.1522730113 26 BrownP.BrandelJ