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1 When IGF-1 binds to IGF-1R, the tyrosine kinase activates the phosphoinositide 3-kinase (PI3K)-AKT pathway and many integral proteins involved in cellular metabolism, apoptosis, cell adhesion, and angiogenesis are regulated within this pathway

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Intrinsic clearance and half-life were calculated [2]

These two medications address some of the same causes of acne such as decreasing sebum production, act as anti-keratinizing agents, reduce hyperpigmentation, inflammation and unclog pores