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[PubMed Citation] Kao SJ, Wang D, Lin HI, Chen HI

10.1155/2021/1497449 167 San MartinA.FonceaR.LaurindoF

If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)